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RP-HPLC Method Development and Validation for Tinidazole and Diloxanide Furose Pharmaceutical Formulation and Its Forced Degradation Studies

Author(s) P. Balakrishanaiah, A. Soujanya, Ravindar Bairam, Manjunath S.Y
Country India
Abstract For the simultaneous measurement of tinidazole and diloxanide furoate in pharmaceutical dosage form, a straightforward, accurate, and exact approach was created. A Waters 2695 HPLC system with an auto sampler, UV detector, and Empower 2 software was used to conduct the chromatography. The Hypersil OSD C18 column (250 x 4.6 mm, 5 µ particle size) was used for the analysis, which was conducted at 278 nm and at 250C. Acetoitrile (45:55V/V) and Phosphate Buffer (KH2PO4) make up the optimum mobile phase. A constant flow rate of 1 ml/min was maintained.Tinidazole and Diloxanide Furoate were determined to have respective purity percentages of 100.24% and 99.64 percent. The theoretical plates, tailing factor, and other system suitability parameters for tinidazole and diloxanide furoate were determined to be 5630, 7362, 1.32, and 1.24, respectively. According to the linearity investigation, the correlation coefficient (r2) for tinidazole and diloxanide furoate was 0.999 and 0.999, respectively, and the mean recovery percentages were 99.85% and 100.21%.The corresponding RSDs for repeatability and intermediate precision were 0.6 and 0.6, respectively. The precision study was repeatable, reliable, and accurate. The study's findings demonstrated the simplicity, accuracy, precision, robustness, speed, and reproducibility of the suggested RP-HPLC approach, which could be helpful for routinely estimating the amounts of tinidazole and diloxanide furoate in pharmaceutical dosage forms.
Keywords Tinidazole, Diloxanide Furoate, RP‐HPLC, Simultaneous estimation
Field Medical / Pharmacy
Published In Volume 6, Issue 1, January 2025
Published On 2025-01-20
Cite This RP-HPLC Method Development and Validation for Tinidazole and Diloxanide Furose Pharmaceutical Formulation and Its Forced Degradation Studies - P. Balakrishanaiah, A. Soujanya, Ravindar Bairam, Manjunath S.Y - IJLRP Volume 6, Issue 1, January 2025.
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