Dr. Saurabh K. Jha

5 Years (Research and Teaching)

PROFESSIONAL MEMBERSHIPS:

• Society of Neurochemistry India (SNCI), (India)-Life member

HANDS-ON EXPERIENCE

• Microbiology: Culturing, Plating, Isolation, Competent cell preparation and Identification and Preservation of Bacteria
• Molecular Biology: Isolation of Bacterial / Plant / Animal / Plasmid DNA, PCR and Restriction Enzyme Digestion, Electrophoresis ,SDS, Polymerase chain reaction (PCR), Paraformaldehyde fixation of tissues, Immunocytochemistry, Hematoxylin and Eosin staining, Chick Chorioallantoic Membrane (CAM) assay
• Biochemistry: Qualitative and Quantitative estimation of Proteins and Carbohydrates and tests for their identification, Paper and Thin Layer Chromatography, UV Spectroscopy, Restriction digestion
• Cell culture: Sub culturing of cell, Drug screening, Cell viability Assays (Trypan blue exclusion test, MTT assay), Microscopic work, SDS-PAGE and Western Blotting
• Animal Model Generation: Parkinson’s disease model, Hypoxia model
• Immunology: Blood group typing, Widal Test, Immuno-diffusion and Immuno-electrophoresis, ELISA
• Bioinformatics: Sequence searching and alignment (BLAST, CLUSTAL W), Auto Dock, Integrated database search (Entrez)

PEER-REVIEWED PUBLICATIONS

• Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Rashmi K. Ambasta, Pravir Kumar (2017), Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration, Biochimica et Biophysica Acta, (BBA Molecular Basis of disease; Biochim Biophys Acta. 2017 May;1863(5)1132-1146. doi 10.1016/j.bbadis.2016.06.015. Epub 2016 Jun 21. Elsevier; ,
• Saurabh Kumar Jha, Pravir Kumar*, (2017) "Molecular docking study of neuroprotactiveplant-derived biomolecules in Parkinsons disease". International Journal of Pharmacy and Pharmaceutical Sciences. Vol 9 Issue 9, Sept 2017.
• Saurabh Kumar Jha, Pravir Kumar*, (2017) “An insilico study of Naringenin mediated neuroprotection in Parkinson Disease”. Asian J Pharm Clin Res. Vol 10, Issue 8, 2017.
• Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj Kumar, Renu Sharma, Abhishek Shrivastava, Rashmi K Ambasta and Pravir Kumar (2017), Stress induced synaptic dysfunction and neurotransmitter release in Alzheimer's disease Can neurotransmitter and Neuromodulator be a potential therapeutic target?, Journal of Alzheimers Disease, J Alzheimers Dis. 2017;57(4)1017-1039. doi 10.3233/JAD-1606232016; ,
• Niraj Kumar Jha, Saurabh Kumar Jha, Renu Sharma, Dhiraj Kumar, Rashmi K Ambasta and Pravir Kumar (2018), Hypoxia induced signaling activation in Neurodegenerative Diseases Targets for new therapeutic strategies, , J Alzheimers Dis. 2018;62(1)15-38. doi 10.3233/JAD-170589.
• Renu Sharma, Dhiraj Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Rashmi K Ambasta and Pravir Kumar (2016), Re-expression of Cell cycle markers in aged Neurons and Muscles Whether cells should divide or die?, Biochimica et Biophysica Acta, (BBA Molecular Basis of disease; Elsevier; 1863(1)324-336, ,
• Saurabh Kumar Jha, Niraj Kumar Jha, Pravir Kumar and Rashmi K Ambasta (2016), Molecular Chaperones and Ubiquitin Proteasome System in Tumor Biogenesis An Overview, Journal of Cell Biology and Cell Metabolism, 3 010
• Saurabh Kumar Jha, Niraj Kumar Jha, Rohan Kar, Rashmi K Ambasta, Pravir Kumar (2015), p38 MAPK and PI3K/AKT signaling in Parkinsons disease, International Journal of Molecular and Cellular Medicine (IJMCM), Spring 2015 2015 Spring;4(2)67-86.
• Rashmi K. Ambasta, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha, and Pravir Kumar (2015) Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules, Accepted September 2015, 13307, Journal of Translational Medicine,
• Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj Kumar, Noopur Kejariwal, Renu Sharma, Rashmi K Ambasta and Pravir Kumar (2015), Impact of IDE and Neprilysin in Alzheimer's disease biology Characterization of putative cognates for therapeutic applications. Accepted Journal of Alzheimers Disease 2015; 48(4)891-917. doi 10.3233/JAD-150379. 14th July 2015,
• Pravir Kumar, Dhiraj Kumar, Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K Ambasta (2015), Ion channels in neurological disorders, Accepted October 2015, Advances in Protein Chemistry and Structural Biology, 2016;10397-136. doi 10.1016/bs.apcsb.2015.10.006. Epub 2015 Nov 28.
• Pravir Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Karunya Ramani and Rashmi K Ambasta (2015), Tau phosphorylation, molecular chaperones, Ubiquitin E3 ligase clinical relevance in Alzheimers disease, Journal of Alzheimers Disease, 2015;43(2)341-61;
• Niraj Kumar Jha, Saurabh Kumar Jha, Rohan Kar, Rashmi K Ambasta and Pravir Kumar (2014), Role of oxidative stress, ER stress and Ubiquitin Proteasome system in neurodegeneration, MOJ Cell Science and Report. 07/2014; 01(2).

BOOK CHAPTER

• Niraj Kumar Jha, Saurabh Kumar Jha, Satyaprakash, Rohan Kar, Deepak Rathore, Rashmi K Ambasta and Pravir Kumar (2015) Epigenetics and angiogenesis in cancer, Epigenetic Advancements in Cancer, Edited by Manoj Mishra, Kumar Bishnupuri, 12/2015 BOOK CHAPTER; Springer International publishing AG. 3

CONFERENCE, PROCEEDINGS AND SYMPOSIUM

• Saurabh Kumar Jha and Pravir Kumar*, (2015), Comparative analysis of biomolecules in Parkinsons disease therapeutics, 29th Annual Conference of Society for Neurochemistry India and Advancement in computation Neurochemistry and Neurobiology (SNCI-ACNN), December 19-21, 2015, NEHU Shillong , INDIA
• Alka Raina, Saurabh Kumar Jha, Niraj Kumar Jha, Dhiraj kumar, Rashmi K Ambasta and Pravir Kumar*(2015), Putative transcription factor binding elements of ubiquitin E3 ligase in neurodegenerative disorders, 29th Annual Conference of Society for Neurochemistry India and Advancement in computation Neurochemistry and Neurobiology (SNCI-ACNN), December 19-21, 2015, NEHU Shillong , INDIA
• Abhisekh Srivastava, Puspendramani Mishra, Dhiraj kumar, Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K Ambasta and Pravir Kumar* (2015), Relevance of terpenoids and alkaloids in neuroprotection, 29th Annual Conference of Society for Neurochemistry India and Advancement in computation Neurochemistry and Neurobiology (SNCI-ACNN), December 19-21, 2015, NEHU Shillong , INDIA
• Swati Sharan, Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj kumar, Rashmi K Ambasta and Pravir Kumar*(2015), Post-translational modification mechanism in Parkinsons disease pathology, 29th Annual Conference of Society for Neurochemistry India and Advancement in computation Neurochemistry and Neurobiology (SNCI-ACNN), December 19-21, 2015, NEHU Shillong , INDIA
• Minal Singh, Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj kumar, Rashmi K Ambasta and Pravir Kumar* (2015), In silico characterization of holo AβPP promoter and its transactivation modules 29th Annual Conference of Society for Neurochemistry India and Advancement in computation Neurochemistry and Neurobiology (SNCI-ACNN), December
• Abhishek Srivastava, Puspendra M Mishra, Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K Ambasta and Pravir Kumar (2015), In silico analysis cannaboids in neurodegeneration, 6th World congress on biotechnology, New Delhi, October 5th-7th, J Biotechnol Biomater 2015, 56, INDIA
• Saurabh Kumar Jha, Niraj Kumar Jha, SatyaPrakash, M. Sonia Angeline, Rashmi K. Ambasta and Pravir Kumar (2014), In silico study of flavonones in neurodegenerative disorders, International Symposium on Translational Neuroscience and XXXII Annual Conference of the Indian Academy of Neurosciences, 01-03 November, NIMHANS Bangalore, INDIA, INDIA
• Niraj Kumar Jha, Saurabh Kumar Jha, Satya Prakash, M. Sonia Angeline, Rashmi K. Ambasta and Pravir Kumar (2014), Physiological stress in neurodegeneration Interatomic partners based on In silco study, International Symposium on Translational Neuroscience and XXXII Annual Conference of the Indian Academy of Neurosciences, 01-03 November, NIMHANS Bangalore, INDIA
• Dhiraj Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Renu Sharma, Kushi Anand, Rashmi K. Ambasta and Pravir Kumar (2014), Anti cancerous drugs as a neuroprotectant a therapeutic intervention in neurodegenerative disorders, International Symposium on Translational Neuroscience and XXXII Annual Conference of the Indian Academy of Neurosciences, 01-03 November, NIMHANS Bangalore, INDIA
• Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K. Ambasta and Pravir Kumar (2013), Structurally and functionally analyzed new generation anti-aging neuroprotective drugs, NCRTPSB 2013, JMI 16-18 December, INDIA Journal of Protein and Proteomics, Vol.4, No.2 p62, INDIA
• Saurabh Kumar Jha, Niraj Kumar Jha, Deepak Rathore, Rashmi K. Ambasta and Pravir kumar (2013), Traditional FDA approved anti-cancerous drugs versus new anti-cancerous drugs A computational approach, 09-11 December, Bioworld Conference, IIT Delhi, INDIA
• Niraj Kumar Jha, Saurabh Kumar Jha, Rashmi K. Ambasta and Pravir kumar (2013) Computer assisted protein analysis in hypoxia signaling, NCRTPSB 2013, JMI 16-18 December, INDIA Journal of Protein and Proteomics, Vol.4, No.2 p37, INDIA
• Niraj Kumar Jha, Lakshmi, Binod Koirala, Saurabh Kumar Jha, Renu Sharma, Rohan Kar, Dhiraj, Jitendra Singh, Rashmi K. Ambasta and Pravir kumar; (2013), Identification and validation of key Ubiquitin E3 ligases in type II diabetes An in silico work; 09-11 December, Bioworld Conference, IIT Delhi, Delhi, INDIA
• P. Asthana, A.Sarkar, S. Angeline, Kushi Anand, N. Jaiswal, S.K. Jha, N.K. Jha, Priya Chaterjee R. K. Ambasta, Pravir Kumar* (2012), “Protective effect of naringenin on hypoxia induced muscles degeneration”. 2012-S-7580-SfN (Poster presentation in the annual meeting of Society of Neuroscience, Oct 17, 2012, New Orleans, Poster, USA.